An inhibitor of HIF-2α PAS-B domain heterodimerization; binds to the HIF-2α PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the ARNT PAS-B domain in cell-free assays from 0.1-100 µM; decreases expression of the HIF-2α target gene VEGFA in 786-O renal carcinoma cells from 0.1-30 µM

HIF-2α Antagonist 2 – 5 mg

Brand:
Cayman
CAS:
1422955-31-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

HIF-2α antagonist 2 is an inhibitor of hypoxia-inducible factor-2α (HIF-2α) PAS-B domain heterodimerization.{53889} It binds to the HIF-2α PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in cell-free assays when used at concentrations ranging from 0.1 to 100 µM. HIF-2α antagonist 2 (0.1-30 µM) decreases expression of the HIF-2α target gene VEGFA in 786-O renal carcinoma cells.  

 

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An inhibitor of HIF-2α PAS-B domain heterodimerization; binds to the HIF-2α PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the ARNT PAS-B domain in cell-free assays from 0.1-100 µM; decreases expression of the HIF-2α target gene VEGFA in 786-O renal carcinoma cells from 0.1-30 µM

Formal name: N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine

Synonyms: 

Molecular weight: 308.7

CAS: 1422955-31-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals||Research Area|Cancer|Transcription Factors

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