A hedgehog pathway inhibitor (EC50 = 0.4 μM for Shh signaling in a reporter assay); inhibits proliferation of GNP cells from 0.1 nM to 25 μM; suppresses Gli1 mRNA levels and increases tumor cell death in a mouse model of Ptc1+/-p53-/- medulloblastoma at 20 and 100 mg/kg; blocks basal and bone morphogenic protein 2-induced chondrogenesis in micromass cultures of mouse limb mesenchymal cells

HhAntag – 5 mg

Brand:
Cayman
CAS:
496794-70-8
Storage:
-20
UN-No:
Non-Hazardous - /

HhAntag is an inhibitor of the Sonic Hedgehog (Shh) pathway (EC50 = 0.4 μM for Shh signaling in a reporter assay).{47559} It inhibits proliferation of GNP cells when used at concentrations ranging from 0.1 nM to 25 μM. In vivo, HhAntag (20 or 100 mg/kg) suppresses Gli1 mRNA levels, a target of Shh signaling, and increases tumor cell death in a mouse model of Ptc1+/-p53-/- medulloblastoma. HhAntag also blocks basal and bone morphogenic protein 2-induced chondrogenesis in micromass cultures of mouse limb mesenchymal cells.{47560}  

 

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SKU: 28296 - 5 mg Category:

Description

A hedgehog pathway inhibitor (EC50 = 0.4 μM for Shh signaling in a reporter assay); inhibits proliferation of GNP cells from 0.1 nM to 25 μM; suppresses Gli1 mRNA levels and increases tumor cell death in a mouse model of Ptc1+/-p53-/- medulloblastoma at 20 and 100 mg/kg; blocks basal and bone morphogenic protein 2-induced chondrogenesis in micromass cultures of mouse limb mesenchymal cells

Formal name: N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxy-benzamide

Synonyms: 

Molecular weight: 450.9

CAS: 496794-70-8

Purity: ≥95%

Formulation: A crystalline solid

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