An inhibitor of SIKs (IC50s = 0.92

HG-9-91-01 – 5 mg

Brand:
Cayman
CAS:
1456858-58-4
Storage:
-20
UN-No:
Non-Hazardous - /

HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs; IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively).{30901} It also inhibits Src, Lck, Yes, and BTK, as well as FGF and Ephrin receptors.{30901} HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in bone marrow-derived macrophages.{30901} SIK inhibitors, including HG-9-91-01, enhance CREB-dependent gene transcription and IL-10 production in bone marrow-derived dendritic cells, THP-1 cells, and human primary macrophages.{30901}  

 

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Description

An inhibitor of SIKs (IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively); increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in bone marrow-derived

Formal name: N-(2,4-dimethoxyphenyl)-N’-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-urea

Synonyms: 

Molecular weight: 567.7

CAS: 1456858-58-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Innate Immunity

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