A nondepolarizing neuromuscular blocking agent; an nAChR receptor antagonist; decreases acetylcholine release induced by carbamoylcholine in isolated cat superior cervical ganglion at 27.4 and 54.8 µg/ml; decreases mean arterial pressure in unanesthetized rats at 40 mg/kg; induces signs of nicotine abstinence in nicotine-dependent rats when administered at a dose of 18 ng

Hexamethonium (bromide) – 100 g

Brand:
Cayman
CAS:
55-97-0
Storage:
-20
UN-No:
Non-Hazardous - /

Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs).{46022,46021} It decreases acetylcholine release induced by carbamoylcholine (Item No. 14486) in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 µg/ml.{46023} It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg.{46024} Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats.{46025} Formulations containing hexamethonium were previously used in the treatment of hypertension.  

 

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SKU: 25505 - 100 g Category:

Description

A nondepolarizing neuromuscular blocking agent; an nAChR receptor antagonist; decreases acetylcholine release induced by carbamoylcholine in isolated cat superior cervical ganglion at 27.4 and 54.8 µg/ml; decreases mean arterial pressure in unanesthetized rats at 40 mg/kg; induces signs of nicotine abstinence in nicotine-dependent rats when administered at a dose of 18 ng, i.c.v.

Formal name: N1,N1,N1,N6,N6,N6-hexamethyl-1,6-hexanediaminium, dibromide

Synonyms: 

Molecular weight: 362.2

CAS: 55-97-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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