A polyketide with diverse biological activities; inhibits growth of HeLa S3

Herboxidiene – 500 µg

Brand:
Cayman
CAS:
142861-00-5
Storage:
-20
UN-No:
Non-Hazardous - /

Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.{40942,40944,46191,46192,46193} It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.{46191} Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.{46192} Herboxidiene (0.05 μM) inhibits HIF-1α mRNA splicing and reduces HIF-1α protein levels in HepG2 cells grown under hypoxic conditions. It also inhibits splicing of p27Kip mRNA in HeLa cells in a concentration-dependent manner via interaction with the SAP155 subunit of the SF3b complex.{40944} Herboxidiene (0.1 and 1 μM) increases LDL receptor promoter-driven transcription in a cell-based reporter assay.{46193} It also exhibits herbicidal activity against wild buckwheat, morning glory, maize, hemp sesbania, and rapeseed when applied at 0.069 kg/hectare.{40942}  

 

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Description

A polyketide with diverse biological activities; inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells (GI50s = 7.4-62 nM); is cytostatic against HUVECs (IC50 = 26 nM); inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs; inhibits HIF-1α mRNA splicing and reduces HIF-1α protein levels in HepG2 cells grown under hypoxic conditions at 0.05 μM; inhibits splicing of p27Kip mRNA in HeLa cells; increases LDL receptor promoter-driven transcription in a cell-based reporter assay at 0.1 and 1 μM; has herbicidal activity against wild buckwheat, morning glory, maize, hemp sesbania, and rapeseed at a rate of 0.069 kg/hectare

Formal name: 5,6-anhydro-6-C-[(2S,3E,5E)-6-[(2S,3S,6R)-6-(carboxymethyl)tetrahydro-3-methyl-2H-pyran-2-yl]-2-methyl-3,5-heptadien-1-yl]-1,4,7-trideoxy-4-methyl-3-O-methyl-L-glycero-L-gluco-heptitol

Synonyms:  GEX1A|Tan 1609

Molecular weight: 438.6

CAS: 142861-00-5

Purity: ≥70%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Polyketides||Product Type|Biochemicals|Pesticides|Herbicides||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer|Angiogenesis||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Toxicology|Environmental|Agriculture

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