A prodrug formulation of HPA which may be useful in various biochemical studies and as a reference standard in analytical work

Heneicosapentaenoic Acid methyl ester – 5 mg

Brand:
Cayman
CAS:
65919-53-1
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Heneicosapentaenoic Acid (HPA) is a fatty acid present in trace amounts in the green algae Bryopsis pennata Lamouroux and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the Δ6 position.{5246} HPA can be used to study the significance of the position of the double bonds in n-3 fatty acids. It incorporates into phospholipids and into triacylglycerol in vivo with the same efficiency as EPA and docosahexaenoic acid (DHA) and exhibits strong inhibition of arachidonic acid synthesis from linoleic acid.{5246} HPA is a poor substrate for prostaglandin H (PGH) synthase and for 5-lipoxygenase but retains the ability to rapidly inactivate PGH synthase.{5246} In certain formulations, HPA methyl ester may serve as a prodrug, which should facilitate uptake of HPA and then be hydrolyzed by esterases to generate the free acid once incorporated into cells. It may also be useful as a reference standard in analytical work.  

 

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SKU: 11622 - 5 mg Category:

Description

A prodrug formulation of HPA which may be useful in various biochemical studies and as a reference standard in analytical work

Formal name: 6Z,9Z,12Z,15Z,18Z-heneicosapentaenoic acid, methyl ester

Synonyms:  HPA methyl ester

Molecular weight: 330.5

CAS: 65919-53-1

Purity: ≥98%

Formulation: A solution in ethanol

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Lipids|Fatty Esters/Ethers||Product Type|Biochemicals|Small Molecule Inhibitors|Prostaglandin Synthases||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Fatty Acids

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