An oxidized form of heme that inhibits eIF2αK1

Hemin chloride – 1 g

Brand:
Cayman
CAS:
16009-13-5
Storage:
-20
UN-No:
Non-Hazardous - /

Hemin chloride is an oxidized form of heme that inhibits eukaryotic translation initiation factor 2α kinase 1 (eIF2αK1), a repressor of eIF-2α.{32368} This alters the initiation of mRNA translation, evoking a wide array of cellular effects. Hemin chloride is used experimentally to induce the expression of heme oxygenase-1 in cells and in animals.{32369,32367,32365} Heme extracted from blood is usually oxidized to hemin chloride.{32366,32364} In porphyria, disorders resulting from an increase in porphyrins, hemin chloride serves to activate feedback inhibition of δ-aminolevulinic acid synthase, reducing heme biosynthesis.{32364}  

 

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Description

An oxidized form of heme that inhibits eIF2αK1, a repressor of eIF-2α; used experimentally to induce the expression of heme oxygenase-1 in cells and in animals

Formal name: (SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,8-dipropanoato(4-)-κN21, κN22, κN23, κN24]-ferrate(2-), dihydrogen

Synonyms: 

Molecular weight: 652

CAS: 16009-13-5

Purity: ≥96%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Blood|Erythrocytes & Hemoglobin

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