A photosensitizer; increases oxygen consumption and decreases the RCR in irradiated isolated rat liver mitochondria at 3 μM; It induces DNA breaks in cell-free assays at 6 μM; decreases the survival of irradiated HeLa cells at 12 μM; decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation at 5 mg/kg

Hematoporphyrin (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
17696-69-4
Storage:
-20
UN-No:
Non-Hazardous - /

Hematoporphyrin is a photosensitizer.{46544} Hematoporphyrin (3 μM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria.{46545} It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 μM.{46546} Hematoporphyrin (12 μM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation.{46547}  

 

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Description

A photosensitizer; increases oxygen consumption and decreases the RCR in irradiated isolated rat liver mitochondria at 3 μM; It induces DNA breaks in cell-free assays at 6 μM; decreases the survival of irradiated HeLa cells at 12 μM; decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation at 5 mg/kg

Formal name: 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid, dihydrochloride

Synonyms:  Haematoporphyrin|Hematoporphyrin IX

Molecular weight: 671.6

CAS: 17696-69-4

Purity: ≥90% (mixture of isomers)

Formulation: A solid

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