An Na+/K+-ATPase inhibitor; high affinity for the α1β1 subunit of the Na+/K+-ATPase; inhibits cancer cell growth (GI50 = 6-58 nM in various human cancer cell lines); induces apoptosis in Jurkat T cells

Hellebrin – 1 mg

Brand:
Cayman
CAS:
13289-18-4
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Hellebrin is a cardiac glycoside that potently inhibits the Na+/K+-ATPase by binding to it and blocking its non-canonical function as a receptor for cardiac glycosides.{34298,34300} Hellebrin has a higher affinity for the α1β1 subunit of the Na+/K+-ATPase than the α2β1 or α3β1 complexes, in contrast to other cardiac glycosides.{34298} This affinity for the α1β1 complex correlates with its cancer cell growth inhibition (GI50 = 6-58 nM in various human cancer cell lines). Hellebrin also induces caspase-dependent apoptosis in Jurkat T cells.{34299}  

 

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Description

An Na+/K+-ATPase inhibitor; high affinity for the α1β1 subunit of the Na+/K+-ATPase; inhibits cancer cell growth (GI50 = 6-58 nM in various human cancer cell lines); induces apoptosis in Jurkat T cells

Formal name: 3β-[(6-deoxy-4-O-β-D-glucopyranosyl-α-L-mannopyranosyl)oxy]-5β,14-dihydroxy-19-oxo-bufa-20,22-dienolide

Synonyms:  NSC 93134

Molecular weight: 724.8

CAS: 13289-18-4

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis

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