Description
A triterpene saponin with diverse biological activities; increases production of ROS, reduces colony formation, and induces apoptosis in cisplatin-resistant HNC cells; suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model at 50, 100, and 200 mg/kg; reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and iNOS protein levels in a rat model of atherosclerosis; reduces ethanol-induced production of TNF-α, IL-6, and COX-2, ALDH2 mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity at 50 mg/kg; induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of MPTP-induced Parkinson’s disease
Formal name: (4α)-3β,23-dihydroxy-olean-12-en-28-oic acid
Synonyms: Astrantiagenin E|Caulosapogenin|Hederagenic Acid|NSC 24954
Molecular weight: 472.7
CAS: 465-99-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Multidrug Resistance||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen