A triterpene saponin with diverse biological activities; increases production of ROS

Hederagenin – 250 mg

Brand:
Cayman
CAS:
465-99-6
Storage:
-20
UN-No:
Non-Hazardous - /

Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities.{48346,48347,48348,48349,48350} It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells.{48347} In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis.{48348} Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity.{48349} It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson’s disease induced by MPTP.{48350}  

 

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Description

A triterpene saponin with diverse biological activities; increases production of ROS, reduces colony formation, and induces apoptosis in cisplatin-resistant HNC cells; suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model at 50, 100, and 200 mg/kg; reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and iNOS protein levels in a rat model of atherosclerosis; reduces ethanol-induced production of TNF-α, IL-6, and COX-2, ALDH2 mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity at 50 mg/kg; induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of MPTP-induced Parkinson’s disease

Formal name: (4α)-3β,23-dihydroxy-olean-12-en-28-oic acid

Synonyms:  Astrantiagenin E|Caulosapogenin|Hederagenic Acid|NSC 24954

Molecular weight: 472.7

CAS: 465-99-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Multidrug Resistance||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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