Description
A saponin with anti-inflammatory activity that inhibits AChE (IC50 = 31.3 μM); inhibits the mutagenicity induced by aflatoxin B1 in S. typhimurium agar cultures from 21-67% at 0.5-5 μg per plate; reduces TNF-α, IL-1β, IL-6, COX-2, and NOS levels and IRAK1 activity in LPS-stimulated mouse peritoneal macrophages at 5-10 μM; reduces carrageenan-induced acute edema in the rat hind paw by 37% compared to vehicle control at 0.02 mg/kg; reduces scopolamine-induced memory impairment and increases latency in a passive avoidance test and spontaneous alteration in a Y-maze in mice by 100 and 59%, respectively, at 40 mg/kg; reduces serum levels of TNF-α and IL-1β by 60 and 65%, respectively, in LPS-challenged mice at 5 mg/kg
Formal name: 3β-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-olean-12-en-28-oic acid, O-6-deoxy-α-L-mannopyranosyl-(1→4α)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester
Synonyms: Hederasaponin C|Kalopanaxsaponin B
Molecular weight: 1,221.40
CAS: 14216-03-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory
