The active form of Hsp inhibitor I; a benzylidene lactam compound; prevents the synthesis of inducible Hsps

Heat Shock Protein Inhibitor II – 25 mg

Brand:
Cayman
CAS:
1859-42-3
Storage:
-20
UN-No:
Non-Hazardous - /

Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I (Item No. 15395) and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice.{25049} At 100 µM, it inhibits the development of thermotolerance in COLO 320 DM cells.{25048} Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B (AmB; Item No. 11636) increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 µg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 µg/ml for combined and AmB alone, respectively) strains of A. fumigatus.{37052}  

 

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Description

The active form of Hsp inhibitor I; a benzylidene lactam compound; prevents the synthesis of inducible Hsps, including Hsp105, Hsp72, and Hsp40; decreases Hsp72 synthesis in vivo; at 100 µM, inhibits the development of thermotolerance in COLO 320 DM cells; reduces thermotolerance of tumors in SCC VII tumor-containing mice; in combination with AmB increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 µg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 µg/ml for combined and AmB alone, respectively) strains of A. fumigatus

Formal name: 3-(1,3-benzodioxol-5-ylmethylene)-2-pyrrolidinone

Synonyms:  Hsp Inhibitor II|KNK 423

Molecular weight: 217.2

CAS: 1859-42-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer||Research Area|Cell Biology|Cellular Chaperones||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis

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