A potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks other HDAC enzymes; cell permeable

HDAC6 Inhibitor – 5 mg

Brand:
Cayman
CAS:
1259296-46-2
Storage:
-20
UN-No:
De Minimis - 1648 / 3

HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates.{26999} In this way, it impacts development, proliferation, invasion, and tumorigenesis.{26999} HDAC6 Inhibitor is a potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks other HDAC enzymes.{24174} It is cell permeable, inhibiting the acetylation of tubulin in cells with an IC50 value of 210 nM.{24174}  

 

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Description

A potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks other HDAC enzymes; cell permeable, inhibiting the acetylation of tubulin in cells with an IC50 value of 210 nM

Formal name: 1,2,3,4-tetrahydro-N-hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-6-isoquinolinecarboxamide

Synonyms:  Histone Deacetylase 6

Molecular weight: 299.3

CAS: 1259296-46-2

Purity: ≥95%

Formulation: A solution in acetonitrile

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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