A cell-permeable

HC Toxin – 1 mg

Brand:
Cayman
CAS:
83209-65-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM).{18728,18472} Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells.{18727,18417} HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.{18726}  

 

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SKU: 10576 - 1 mg Category:

Description

A cell-permeable, reversible inhibitor of HDACs (IC50 = 30 nM)

Formal name: (6R,9S,14aR)-3,6R-dimethyl-9S-(6-((S)-oxiran-2-yl)-6-oxohexyl)decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetranone

Synonyms:  Toxin I (Helminthosporium carbonum)

Molecular weight: 436.5

CAS: 83209-65-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Product Type|Biochemicals|Toxins||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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