An inhibitor of mitochondrial complex II (SQR; IC50s = 0.017

Harzianopyridone – 1 mg

Brand:
Cayman
CAS:
137813-88-8
Storage:
-20
UN-No:
Non-Hazardous - /

Harzianopyridone is an atpenin-like inhibitor of mammalian and nematode mitochondrial complex II (succinate:ubiquinone oxidoreductase; SQR) with IC50 values of 0.017, 0.2, and 2 μM for bovine, rat, and nematode complex II, respectively.{21748} It also inhibits nematode quinol-fumarate reductase (QFR; IC50 = 0.36 μM). Harzianopyridone is selective for complex II over complexes I and III in rats and cattle and complex I in nematodes (IC50s >100 μM). It has antibacterial and antifungal activity (EC50s = 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively).{41147,41146}  

 

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Description

An inhibitor of mitochondrial complex II (SQR; IC50s = 0.017, 0.2, and 2 μM for bovine, rat, and A. suum nematode, respectively); inhibits QFR of A. suum (IC50 = 0.36 μM); selective for complex II over complexes I and III in rats and cattle and complex I in nematodes (IC50s >100 μM); has antibacterial and antifungal activity (EC50s = 35.9, 42.2, 60.4, and 50.2 μg/ml for R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively).

Formal name: 4-hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexen-1-yl]-2(1H)-pyridinone

Synonyms:  (-)-Harzianopyridone

Molecular weight: 281.3

CAS: 137813-88-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cell Biology|Mitochondrial Biology

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