A small molecule inhibitor of RPA; selectively binds to and inhibits DBD-F on RPA70 up to 100 µM; inhibits etoposide-induced autophosphorylation of ATR kinase and subsequent phosphorylation of RPA32 in UMSCC38 cells at 10 and 20 µM; reduces tumor growth in UMSCC11B and UMSCC38 mouse xenograft models at 1 mg/kg when used in combination with etoposide

HAMNO – 10 mg

Brand:
Cayman
CAS:
138736-73-9
Storage:
-20
UN-No:
Non-Hazardous - /

HAMNO is a small molecule inhibitor of replication protein A (RPA).{45417} It selectively binds to and inhibits DNA binding domain F (DBD-F) on RPA70 when used at concentrations up to 100 µM. HAMNO inhibits etoposide-induced autophosphorylation of ATR kinase and subsequent phosphorylation of RPA32 in UMSCC38 cells when used at concentrations of 10 and 20 µM. HAMNO (1 mg/kg), in combination with etoposide (Item No. 12092), reduces tumor growth in UMSCC11B and UMSCC38 mouse xenograft models.  

 

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SKU: 27631 - 10 mg Category:

Description

A small molecule inhibitor of RPA; selectively binds to and inhibits DBD-F on RPA70 up to 100 µM; inhibits etoposide-induced autophosphorylation of ATR kinase and subsequent phosphorylation of RPA32 in UMSCC38 cells at 10 and 20 µM; reduces tumor growth in UMSCC11B and UMSCC38 mouse xenograft models at 1 mg/kg when used in combination with etoposide

Formal name: 1-[[(2-hydroxyphenyl)amino]methylene]-2(1H)-naphthalenone

Synonyms: 

Molecular weight: 263.3

CAS: 138736-73-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer

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