A typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6

Haloperidol – 100 mg

Brand:
Cayman
CAS:
52-86-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Haloperidol is a typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6, 0.2, and 22 nM, for D2, D3, and D4 receptors, respectively).{25512} It also acts as an inverse agonist at dopamine D2 and D3 receptors (IC50s = 0.8 and 0.6 nM, respectively). Haloperidol also binds to α1- and α2- adrenergic and histamine H1 receptors, as well as the serotonin (5-HT) receptor subtypes 5-HT1D and 5-HT2A (Kds = 17, 600, 260, 40, and 61 nM, respectively).{25511} It inhibits stereotypic behavior induced by apomorphine (Item No. 16094) and amphetamine in rats (ID50s = 0.532 and 0.101 μmol/kg, respectively).{46010} Haloperidol also inhibits apomorphine-induced decreases in prepulse inhibition of the acoustic startle response in rats in a dose-dependent manner.{46011} Formulations containing haloperidol have been used in the treatment of schizophrenia and Tourette syndrome.  

 

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SKU: 12014 - 100 mg Category:

Description

A typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6, 0.2, and 22 nM, for D2, D3, and D4 receptors, respectively); An inverse agonist at D2 and D3 receptors (IC50s = 0.8 and 0.6 nM, respectively); binds to α1- and α2- adrenergic and histamine H1 receptors, as well as 5-HT receptor subtypes 5-HT1D and 5-HT2A (Kds = 17, 600, 260, 40, and 61 nM, respectively); inhibits stereotypic behavior induced by apomorphine and amphetamine in rats (ID50s = 0.532 and 0.101 μmol/kg, respectively); inhibits apomorphine-induced decreases in prepulse inhibition of the acoustic startle response in rats in a dose-dependent manner

Formal name: 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone

Synonyms:  McN-JR 1625|NSC 170973|NSC 615296|R 1625

Molecular weight: 375.9

CAS: 52-86-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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