A selective autotaxin inhibitor (IC50 = 5.7 nM) that has been shown to dose-dependently block thrombin-induced LPA secretion in platelets

HA-155 – 10 mg

Brand:
Cayman
CAS:
1229652-22-5
Storage:
-20
UN-No:
Non-Hazardous - /

Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. HA-155 is a boronic acid-based compound that inhibits autotaxin (IC50 = 5.7 nM) by selectively binding to its catalytic threonine.{19277,28701} It has been shown to dose-dependently block thrombin-induced LPA secretion in platelets.{28702}  

 

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SKU: 11034 - 10 mg Category:

Description

A selective autotaxin inhibitor (IC50 = 5.7 nM) that has been shown to dose-dependently block thrombin-induced LPA secretion in platelets

Formal name: B-[4-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid

Synonyms:  Autotaxin Inhibitor IV

Molecular weight: 463.3

CAS: 1229652-22-5

Purity: ≥95% (mixture of isomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area

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