An inhibitor of PKG and PKA (Kis = 1.4 and 2.3 µM

HA-1004 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
92564-08-4
Storage:
-20
UN-No:
Non-Hazardous - /

HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 µM, respectively).{48086} It also inhibits PKC and blocks intracellular calcium mobilization.{48087,48088} HA-1004 induces relaxation of isolated rabbit aortic strips precontracted with histamine, serotonin (Item No. 14332), A23187 (Item No. 11016), angiotensin II (Item No. 17150), or prostaglandin F2α (Item No. 16010; EC50s = 0.32-0.63 µM), as well as phenylephrine (Item Nos. 18619 | 17205) with or without calcium (EC50s = 2.3 and 0.5 µM, respectively). It also inhibits histamine-induced bronchoconstriction in guinea pigs without affecting blood pressure when administered intratracheally at a dose of 0.1 mg per animal.{48087}  

 

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SKU: 10010558 - 5 mg Category:

Description

An inhibitor of PKG and PKA (Kis = 1.4 and 2.3 µM, respectively); induces relaxation of isolated rabbit aortic strips precontracted with a variety of agonists (EC50s = 0.32-0.63 µM), as well as phenylephrine with or without calcium (EC50s = 2.3 and 0.5 µM, respectively); inhibits histamine-induced bronchoconstriction in guinea pigs without affecting blood pressure at 0.1 mg per animal

Formal name: N-[2-[(aminoiminomethyl)amino]ethyl]-5-isoquinolinesulfonamide, dihydrochloride

Synonyms: 

Molecular weight: 366.3

CAS: 92564-08-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Kinase Inhibitors|PKD & PKG||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation|Allergy

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