A potent competitive inhibitor of PKC

H-9 (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
116700-36-8
Storage:
-20
UN-No:
Non-Hazardous - /

The H series isoquinolinesulfonamide protein kinase inhibitors are widely used to block signaling pathways in order to elucidate mechanisms of cellular regulation and signal transduction. H-9 (hydrochloride), an isoquinolinesulfonamide protein kinase inhibitor, is a competitive inhibitor of PKC, PKG, and PKA with Ki values of 18, 0.87, and 1.9 µM, respectively.{16079} H-9 (hydrochloride) has been used to reduce the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons{17222} and to inhibit PKA-mediated phosphorylation in a rat seizure model.{17221}  

 

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Description

A potent competitive inhibitor of PKC, PKG, and PKA with Ki values of 18, 0.87, and 1.9 µM, repectively

Formal name: N-(2-aminoethyl)-5-isoquinolinesulfonamide, dihydrochloride

Synonyms:  Protein Kinase Inhibitor H-9

Molecular weight: 324.2

CAS: 116700-36-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Kinase Inhibitors|PKD & PKG||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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