A STING inhibitor; forms an adduct with mouse STING in serum and acts in an irreversible manner; inhibits the type I IFN response in vitro; reduces phosphorylation of TBK1 and palmitoylation of hsSTING; reduces CMA-induced increases in mouse serum levels of IFN-β and IL-6

H-151 – 100 mg

Brand:
Cayman
CAS:
941987-60-6
Storage:
-20
UN-No:
Non-Hazardous - /

H-151 is an inhibitor of stimulator of interferon genes (STING).{35390} It forms an adduct with mouse STING in serum and acts in an irreversible manner. It inhibits the type I interferon (IFN) response and reduces the phosphorylation of TBK1 and palmitoylation of human STING (hsSTING) in vitro. It also reduces increases in mouse serum levels of IFN-β and IL-6 induced by the STING agonist 10-carboxymethyl-9-acridanone (CMA).  

 

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SKU: 25857 - 100 mg Category:

Description

A STING inhibitor; forms an adduct with mouse STING in serum and acts in an irreversible manner; inhibits the type I IFN response in vitro; reduces phosphorylation of TBK1 and palmitoylation of hsSTING; reduces CMA-induced increases in mouse serum levels of IFN-β and IL-6

Formal name: N-(4-ethylphenyl)-N’-1H-indol-3-yl-urea

Synonyms: 

Molecular weight: 279.3

CAS: 941987-60-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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