Inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I

GZD-824 – 10 mg

Brand:
Cayman
CAS:
1257628-77-5
Storage:
-20
UN-No:
Non-Hazardous - /

GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively).{33583} It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC50s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl.{33583}  

 

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Description

Inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively); suppresses proliferation of Bcr/Abl-positive K562 and Ku812 CML cells (IC50s = 0.2 and 0.13 nM, respectively) and induces tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl

Formal name: 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-benzamide

Synonyms: 

Molecular weight: 532.6

CAS: 1257628-77-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Abl Family & Bcr-Abl||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Abl family & Bcr-Abl Signaling

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