A dammarane-type triterpene saponin; prevents increases in iNOS

Gypenoside IX – 50 mg

Brand:
Cayman
CAS:
80321-63-7
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Gypenoside IX is a dammarane-type triterpene saponin that has been found in P. notoginseng.{48933} It prevents increases in inducible nitric oxide synthase (iNOS), IL-6, and TNF-α levels, as well as phosphorylation of NF-κB, IκB, p38 MAPK, and Akt, induced by LPS and TNF-α in rat C6 glial cells when used at a concentration of 25 μM.{48934} In vivo, gypenoside IX (30 mg/kg per day) reduces LPS-induced increases in NF-κB, IκB, p38 MAPK, and Akt phosphorylation in mouse brain cortex.  

 

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SKU: 29705 - 50 mg Category:

Description

A dammarane-type triterpene saponin; prevents increases in iNOS, IL-6, and TNF-α levels, as well as phosphorylation of NF-κB, IκB, p38 MAPK, and Akt, induced by LPS and TNF-α in rat C6 glial at 25 μM; reduces LPS-induced increases in NF-κB, IκB, p38 MAPK, and Akt phosphorylation in mouse brain cortex at 30 mg/kg per day

Formal name: (3β)-3-(β-D-glucopyranosyloxy)-12β-hydroxydammar-24-en-20-yl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside

Synonyms:  Notoginsenoside Fd

Molecular weight: 917.1

CAS: 80321-63-7

Purity: ≥95%

Formulation: A crystalline solid

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