GW 7647 is a potent

GW 7647 – 1 mg

Brand:
Cayman
CAS:
265129-71-3
Storage:
-20
UN-No:
Non-Hazardous - /

Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.{6374,4136} Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport.{11955} GW 7647 is a potent, selective agonist of human and murine PPARα{14085} It activates human PPARα, PPARγ, and PPARδ with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.{14085}  

 

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SKU: 10008613 - 1 mg Category:

Description

GW 7647 is a potent, selective agonist of human and murine PPARα{14085} It activates human PPARα, PPARγ, and PPAR.delta. with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.{14085}

Formal name: 2-methyl-2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-propanoic acid

Synonyms: 

Molecular weight: 502.8

CAS: 265129-71-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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