An antagonist of PPARα (IC50 = 240 nM)

GW 6471 – 1 mg

Brand:
Cayman
CAS:
880635-03-0
Storage:
-20
UN-No:
Non-Hazardous - /

The peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation.{7654,14916,20898} GW 6471 is an antagonist of PPARα (IC50 = 240 nM).{23912} It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor.{23912} GW 6471 is used in cell-free, cell lysate, and whole cell systems to examine the impact of PPARα antagonism.{23911,23910,23913}  

 

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SKU: 11697 - 1 mg Category:

Description

An antagonist of PPARα (IC50 = 240 nM), promoting the recruitment of co-repressor proteins; used in cell-free, cell lysate, and whole cell systems

Formal name: N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-propanamide

Synonyms: 

Molecular weight: 619.7

CAS: 880635-03-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs

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