A potent

GW 5074 – 1 mg

Brand:
Cayman
CAS:
220904-83-6
Storage:
-20
UN-No:
Non-Hazardous - /

Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway.{14539,15155} This pathway mediates basic cellular functions, including proliferation, differentiation, and survival.{14539} GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM).{24584} It blocks phosphorylation of ERK1/2 by 90% in cells stimulated with epidermal growth factor when given at 5 µM.{24584} GW 5074 shows more than 100-fold selectivity for Raf-1 versus several related kinases.{24584}  

 

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SKU: 10010368 - 1 mg Category:

Description

A potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM); blocks phosphorylation of ERK1/2 by 90% in cells stimulated with EGF when given at 5 µM; shows more than 100-fold selectivity for Raf-1 versus several related kinases

Formal name: 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one

Synonyms: 

Molecular weight: 520.9

CAS: 220904-83-6

Purity: ≥98% (mixture of cis and trans)

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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