Description
An inhibitor of neutrophil elastase (Ki = 0.31 nM); selective for human neutrophil elastase (IC50 = 22 nM) over trypsin, cathepsin G, and plasmin (IC50s = >100 µM for all), as well as chymotrypsin and tissue plasminogen activator (IC50s >3 µM for all), in a cell-free assay; inhibits neutrophil elastase activity in isolated dog whole blood and in the liver in a mouse model of liver ischemia-reperfusion injury at 2 mg/kg
Formal name: (3S,3aS,6aR)-hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-buten-1-yl]-pyrrolo[3,2-b]pyrrol-2(1H)-one, monohydrochloride
Synonyms:
Molecular weight: 434
CAS: 197890-44-1
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation|Innate Immunity
