An inhibitor of GABA uptake (IC50 = 10 μM; Ki = 14 μM) in rat hippocampal brain slices; decreases spontaneous activity in mice; decreases tail flick reaction time in a rat model of morphine analgesia

Guvacine (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
6027-91-4
Storage:
-20
UN-No:
Non-Hazardous - /

Guvacine is an amino acid found in A. catechu (Betel nut).{36158} It competitively inhibits GABA uptake (IC50 = 10 μM; Ki = 14 μM) in rat hippocampal brain slices.{36158,36159} In vivo, guvacine, at doses ranging from 50-100 mg/kg, decreases spontaneous activity in mice.{36158} Administration of guvacine also decreases tail flick reaction time in a rat model of morphine analgesia.{36160}  

 

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Description

An inhibitor of GABA uptake (IC50 = 10 μM; Ki = 14 μM) in rat hippocampal brain slices; decreases spontaneous activity in mice; decreases tail flick reaction time in a rat model of morphine analgesia

Formal name: 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, monohydrochloride

Synonyms: 

Molecular weight: 163.6

CAS: 6027-91-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Pain Research

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