A guanidinium derivative with antihypertensive properties; binds to non-adrenergic sites in pig kidney membranes (IC50 = 10 nM); inhibits the Na+/H+ exchanger in pig kidney membranes (IC50 = 1 μM); inhibits cell-free bovine dopamine β-hydroxylase (IC50 = 90 μM); inhibits electrically-stimulated norepinephrine release from spleen; decreases heart

Guanoclor – 25 mg

Brand:
Cayman
CAS:
5001-32-1
Storage:
-20
UN-No:
Non-Hazardous - /

Guanoclor is an antihypertensive agent that binds to non-adrenergic sites in pig kidney membranes (IC50 = 10 nM).{45588,45589} It inhibits the Na+/H+ exchanger in pig kidney membranes (IC50 = 1 μM) and cell-free bovine dopamine β-hydroxylase (IC50 = 90 μM). Guanoclor inhibits electrically stimulated norepinephrine release from spleen.{45588} It decreases norepinephrine levels in dog heart, spleen, hypothalamus, and adrenal gland when administered at a dose of 10 mg/kg per day for six weeks. It decreases adrenal catecholamine levels in rats when administered at a dose of 20 mg/kg per day for six weeks. Guanoclor (20 mg/kg) decreases experimentally induced hypertension and the tyramine-induced pressor response and increases the norepinephrine-induced pressor response in non-anesthetized dogs.  

 

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Description

A guanidinium derivative with antihypertensive properties; binds to non-adrenergic sites in pig kidney membranes (IC50 = 10 nM); inhibits the Na+/H+ exchanger in pig kidney membranes (IC50 = 1 μM); inhibits cell-free bovine dopamine β-hydroxylase (IC50 = 90 μM); inhibits electrically-stimulated norepinephrine release from spleen; decreases heart, spleen, hypothalamus, and adrenal norepinephrine content in dogs at 10 mg/kg per day for 6 weeks; decreases adrenal catecholamine levels in rats at a 20 mg/kg per day for 6 weeks; decreases experimentally-induced hypertension and tyramine-induced pressor response and increases norepinephrine-induced pressor response in non-anesthetized dogs at 20 mg/kg

Formal name: 2-[2-(2,6-dichlorophenoxy)ethyl]-hydrazinecarboximidamide

Synonyms:  Guanochlor

Molecular weight: 263.1

CAS: 5001-32-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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