A guanidinium derivative with antihypertensive properties; binds to non-adrenergic sites in pig kidney membranes (IC50 = 10 nM); inhibits the Na+/H+ exchanger in pig kidney membranes (IC50 = 1 μM); inhibits cell-free bovine dopamine β-hydroxylase (IC50 = 90 μM); inhibits electrically-stimulated norepinephrine release from spleen; decreases heart

Guanoclor – 10 mg

Brand:
Cayman
CAS:
5001-32-1
Storage:
-20
UN-No:
Non-Hazardous - /

Guanoclor is an antihypertensive agent that binds to non-adrenergic sites in pig kidney membranes (IC50 = 10 nM).{45588,45589} It inhibits the Na+/H+ exchanger in pig kidney membranes (IC50 = 1 μM) and cell-free bovine dopamine β-hydroxylase (IC50 = 90 μM). Guanoclor inhibits electrically stimulated norepinephrine release from spleen.{45588} It decreases norepinephrine levels in dog heart, spleen, hypothalamus, and adrenal gland when administered at a dose of 10 mg/kg per day for six weeks. It decreases adrenal catecholamine levels in rats when administered at a dose of 20 mg/kg per day for six weeks. Guanoclor (20 mg/kg) decreases experimentally induced hypertension and the tyramine-induced pressor response and increases the norepinephrine-induced pressor response in non-anesthetized dogs.  

 

Available on backorder

Add to quotes
SKU: 27659 - 10 mg Category:

Description

A guanidinium derivative with antihypertensive properties; binds to non-adrenergic sites in pig kidney membranes (IC50 = 10 nM); inhibits the Na+/H+ exchanger in pig kidney membranes (IC50 = 1 μM); inhibits cell-free bovine dopamine β-hydroxylase (IC50 = 90 μM); inhibits electrically-stimulated norepinephrine release from spleen; decreases heart, spleen, hypothalamus, and adrenal norepinephrine content in dogs at 10 mg/kg per day for 6 weeks; decreases adrenal catecholamine levels in rats at a 20 mg/kg per day for 6 weeks; decreases experimentally-induced hypertension and tyramine-induced pressor response and increases norepinephrine-induced pressor response in non-anesthetized dogs at 20 mg/kg

Formal name: 2-[2-(2,6-dichlorophenoxy)ethyl]-hydrazinecarboximidamide

Synonyms:  Guanochlor

Molecular weight: 263.1

CAS: 5001-32-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Endocrinology & Metabolism|Hormones & Receptors

Related products

  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 10 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 100 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 100 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 500 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 500 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 10 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page