An inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 µM for c-Fms

GTP 14564 – 5 mg

Brand:
Cayman
CAS:
34823-86-4
Storage:
-20
UN-No:
Non-Hazardous - /

GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 µM for c-Fms, c-Kit, ITD-FLT3 and 1 µM for PDGFRβ).{28667} It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases.{28667} GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.{28667,28668}  

 

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Description

An inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 µM for c-Fms, c-Kit, ITD-FLT3 and 1 µM for PDGFRβ); blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5

Formal name: 3-phenyl-1H-benzofuro[3,2-c]pyrazole

Synonyms: 

Molecular weight: 234.3

CAS: 34823-86-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs

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