An ATP-competitive

GSK690693 – 1 mg

Brand:
Cayman
CAS:
937174-76-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

GSK690693 is an ATP-competitive, pan-Akt kinase inhibitor with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively.{27556} It also inhibits other members of the AGC kinase family, including AMPK, DAPK3, PAKs, PKA, PKC, PKG, and PrkX (IC50 values range from 2-81 nM).{27556} By preventing the phosphorylation of downstream Akt substrates, GSK690693 has been shown to inhibit proliferation and to induce apoptosis in various human tumor cells in vitro and in xenografts in immunocompromised mice.{27556}  

 

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Description

An ATP-competitive, pan-Akt kinase inhibitor (IC50s = 2, 13, and 9 nM for Akt1, 2, and 3, respectively) that inhibits proliferation and induces apoptosis in various human tumor cells in vitro and in xenografts in immunocompromised mice

Formal name: 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

Synonyms: 

Molecular weight: 425.5

CAS: 937174-76-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Kinase Inhibitors|PKD & PKG||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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