An SGK1 inhibitor (IC50s = 62 and 103 nM for SGK1 and SGK2

GSK650394 – 10 mg

Brand:
Cayman
CAS:
890842-28-1
Storage:
-20
UN-No:
Non-Hazardous - /

GSK650394 is an inhibitor of serum- and glucocorticoid-regulated kinase (IC50s = 62 and 103 nM for SGK1 and SGK2, respectively).{28036} It demonstrates greater than 30-fold selectivity for SGK1 over Akt and other related kinases.{28036} GSK650394 can inhibit the androgen-stimulated growth of human prostate carcinoma LNCaP cells with an IC50 value of ~ 1 μM.{28036}  

 

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Description

An SGK1 inhibitor (IC50s = 62 and 103 nM for SGK1 and SGK2, respectively) that demonstrates greater than 30-fold selectivity for SGK1 over Akt and other related kinases; inhibits the androgen-stimulated growth of human prostate carcinoma LNCaP cells (IC50 ~ 1 μM)

Formal name: 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid

Synonyms: 

Molecular weight: 382.5

CAS: 890842-28-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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