An AMPK activator that reduces the proliferation of AML cell lines (IC50s = 13-30 μM)

GSK621 – 25 mg

Brand:
Cayman
CAS:
1346607-05-3
Storage:
-20
UN-No:
Non-Hazardous - /

GSK621 is an activator of AMP-activated protein kinase (AMPK). It has been shown to increase phosphorylation at AMPKα T172, a marker of AMPK activation, in both acute myeloid leukemia (AML) cell lines and primary AML samples.{31816} GSK621 is reported to reduce the proliferation of AML cell lines (IC50s = 13-30 μM), triggering autophagy via the eIF2α/ATF4 signaling pathway.{31816}  

 

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Description

An AMPK activator that reduces the proliferation of AML cell lines (IC50s = 13-30 μM), triggering autophagy via the eIF2α/ATF4 signaling pathway

Formal name: 6-chloro-5-(2′-hydroxy-3′-methoxy[1,1′-biphenyl]-4-yl)-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione

Synonyms: 

Molecular weight: 489.9

CAS: 1346607-05-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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