A selective inhibitor of RIP1 that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM; inhibits RIP1 from human and cynomolgus monkey but is at least 100-fold less potent against non-primate RIP1

GSK481 – 10 mg

Brand:
Cayman
CAS:
1622849-58-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

GSK481 is an inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1 or RIPK1) that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM.{33779} It is selective for RIP1 over a panel of over 450 other kinases, including RIP3.{33778,33779} GSK481 inhibits RIP1 from human and cynomolgus monkey but is at least 100-fold less potent against non-primate RIP1.{33779}  

 

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Description

A selective inhibitor of RIP1 that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM; inhibits RIP1 from human and cynomolgus monkey but is at least 100-fold less potent against non-primate RIP1

Formal name: 5-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-3-isoxazolecarboxamide

Synonyms: 

Molecular weight: 377.4

CAS: 1622849-58-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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