A cell-permeable inhibitor of ROCK (IC50 = 14 nM); reverses adrenalin-induced contraction of rat aortic rings (IC50 = 190 nM); produces a dose-dependent decrease in mean arterial pressure in spontaneously-hypertensive rats

GSK429286A – 1 mg

Brand:
Cayman
CAS:
864082-47-3
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

GSK429286A is a cell-permeable inhibitor of Rho-associated kinase (IC50 = 14 nM).{26327} It less potently inhibits p90 and p70 ribosomal S6 kinases (IC50s = 780 and 1,940 nM, respectively) and is ineffective against leucine-rich repeat protein kinase-2.{26327,26328} GSK429286A reverses adrenalin-induced contraction of rat aortic rings (IC50 = 190 nM) and produces a dose-dependent decrease in mean arterial pressure in spontaneously-hypertensive rats.{26327}  

 

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Description

A cell-permeable inhibitor of ROCK (IC50 = 14 nM); reverses adrenalin-induced contraction of rat aortic rings (IC50 = 190 nM); produces a dose-dependent decrease in mean arterial pressure in spontaneously-hypertensive rats

Formal name: N-(6-fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyridinecarboxamide

Synonyms: 

Molecular weight: 432.4

CAS: 864082-47-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|ROCK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cell Biology|Cell Signaling

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