A PCAF/GCN5 bromodomain inhibitor (Ki = 1.4 nM; IC50 = 60 nM in a chromatin engagement assay); >18

GSK4027 – 1 mg

Brand:
Cayman
CAS:
2079896-25-4
Storage:
-20
UN-No:
Non-Hazardous - /

GSK4027 is a p300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) bromodomain inhibitor (Ki = 1.4 nM; IC50 = 60 nM in a chromatin engagement assay).{42858} It is greater than 18,000-fold selective for PCAF and GCN5 over BET family bromodomains and greater than 70-fold selective over other bromodomain families in a BROMOscan assay.  

 

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SKU: 23421 - 1 mg Category:

Description

A PCAF/GCN5 bromodomain inhibitor (Ki = 1.4 nM; IC50 = 60 nM in a chromatin engagement assay); >18,000-fold selective for PCAF and GCN5 over BET family bromodomains and >70-fold selective over other bromodomain families in a BROMOscan assay,

Formal name: 4-bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenyl-3-piperidinyl]amino]-3(2H)-pyridazinone

Synonyms: 

Molecular weight: 377.3

CAS: 2079896-25-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation

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