An inhibitor of GSK3 (34% inhibition when used at a concentration of 2.5 µM); inhibits androgen receptor transactivation and translocation to the nucleus in PCa prostate cancer cells; increases nuclear export of the androgen receptor in PC3 prostate cancer cells; dose-dependently potentiates peak current densities

GSK3 Inhibitor XIII – 1 mg

Brand:
Cayman
CAS:
404828-08-6
Storage:
-20
UN-No:
Non-Hazardous - /

GSK3 Inhibitor XIII is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 µM.{40152} It inhibits androgen receptor transactivation in 22Rv1, LNCaP, and LNCaP-SSR cell lines in a dose-dependent manner. It promotes nuclear export of the androgen receptor and decreases translocation to the nucleus in PC3 and PCa prostate cancer cells, respectively.{40152,40153} In HEK293 cells expressing the rat Nav1.2 channel, pretreatment with GSK3 inhibitor XIII dose-dependently potentiates peak current densities.{40151}  

 

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Description

An inhibitor of GSK3 (34% inhibition when used at a concentration of 2.5 µM); inhibits androgen receptor transactivation and translocation to the nucleus in PCa prostate cancer cells; increases nuclear export of the androgen receptor in PC3 prostate cancer cells; dose-dependently potentiates peak current densities

Formal name: 5,6,7,8-tetrahydro-N-(5-methyl-1H-pyrazol-3-yl)-2-phenyl-4-quinazolinamine

Synonyms:  Glycogen Synthase Kinase 3 Inhibitor XIII

Molecular weight: 305.4

CAS: 404828-08-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|GSK3 Signaling

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