A potent inhibitor of GSK3β (IC50 = 390 nM) that does not inhibit GSK-3α

GSK3β Inhibitor II – 5 mg

Brand:
Cayman
CAS:
478482-75-6
Storage:
-20
UN-No:
Non-Hazardous - /

GSK3β Inhibitor II is a potent inhibitor of glycogen synthase kinase-3β (GSK3β; IC50 = 390 nM) that does not inhibit GSK-3α.{32116} Also referred to as tip-oxadiazole, this compound blocks the functional regulation of p53 by GSK3β, decreasing levels of MDM2, p21, and Bax and modulating mitochondrial p53 apoptotic signaling.{32117} GSK3β Inhibitor II also blocks GSK3β-mediated Tau phosphorylation and Aβ25-35-induced memory impairment in mouse hippocampus.{32115}  

 

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Description

A potent inhibitor of GSK3β (IC50 = 390 nM) that does not inhibit GSK-3α

Formal name: 4-[5-[[(3-iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]-pyridine

Synonyms:  ​Glycogen Synthase Kinase 3β​​ Inhibitor II|Tip-oxadiazole

Molecular weight: 395.2

CAS: 478482-75-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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