An inhibitor of GSK3β (IC50 = 64 nM); induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 µM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt; induces proliferation of R7T1 β-cells (EC50 = 1

GSK3β Inhibitor XVIII – 10 mg

Brand:
Cayman
CAS:
1139875-74-3
Storage:
-20
UN-No:
Non-Hazardous - /

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM).{47416} It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 µM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac (Item No. 10004386), and rat primary β-cells.  

 

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Description

An inhibitor of GSK3β (IC50 = 64 nM); induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 µM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt; induces proliferation of R7T1 β-cells (EC50 = 1,143 nM) and rat primary β-cells

Formal name: [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-methanone

Synonyms: 

Molecular weight: 413.9

CAS: 1139875-74-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Neuroscience

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