A RIPK2 inhibitor; inhibits RIPK2 by 65% in a kinase assay at 10 µM; inhibits VEGFR3 by greater than 90%

GSK2983559 – 1 mg

Brand:
Cayman
CAS:
1579965-12-0
Storage:
-20
UN-No:
Non-Hazardous - /

GSK2983559 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor.{54446} It inhibits RIPK2 by 65% in a kinase assay when used at a concentration of 10 µM. GSK2983559 (10 µM) also inhibits VEGFR3 by greater than 90%, as well as 14 additional kinases by 60 to 89% in a panel of 344 kinases. In vivo, GSK2983559 (7.5 and 145 mg/kg twice per day) reduces colonic damage in a mouse model of TNBS-induced colitis. GSK2983559 is also a prodrug that is cleaved to an active metabolite in the gastrointestinal tract that inhibits RIPK2 more potently than GSK2983559.  

 

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SKU: 31458 - 1 mg Category:

Description

A RIPK2 inhibitor; inhibits RIPK2 by 65% in a kinase assay at 10 µM; inhibits VEGFR3 by greater than 90%, as well as 14 additional kinases by 60-89% in a panel of 344 kinases at 10 µM; reduces colonic damage in a mouse model of TNBS-induced colitis at 7.5 and 145 mg/kg twice per day; a prodrug

Formal name: 2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]-ethanol, 1-(dihydrogen phosphate)

Synonyms: 

Molecular weight: 538.5

CAS: 1579965-12-0

Purity: ≥98%

Formulation: A crystalline solid

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