An ASBT inhibitor (IC50s = 42

GSK2330672 – 1 mg

Brand:
Cayman
CAS:
1345982-69-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

GSK2330672 is an inhibitor of the apical sodium-dependent bile acid transporter (ASBT; IC50s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively).{42065} In vivo, GSK2330672 (0.05 mg/kg) stimulates fecal bile acid secretion, reduces hemoglobin A1c (HbA1c) and plasma glucose levels, and increases total GLP-1 (Item No. 24460) and plasma insulin in Zucker diabetic fatty (ZDF) rats.  

 

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SKU: 23843 - 1 mg Category:

Description

An ASBT inhibitor (IC50s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively); stimulates fecal bile acid secretion, reduces HbA1c and plasma glucose levels, and increases total GLP-1 and plasma insulin levels in ZDF rats,

Formal name: 3-[[[(3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl]methyl]amino]-pentanedioic acid

Synonyms: 

Molecular weight: 546.7

CAS: 1345982-69-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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