A selective agonist of GPR120 (EC50s = 0.5

GSK137647A – 50 mg

Brand:
Cayman
CAS:
349085-82-1
Storage:
-20
UN-No:
Non-Hazardous - /

GPR120 (Free Fatty Acid Receptor 4; FFAR4) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.{27421,22326} GSK137647A is a diarylsulfonamide that acts as a selective agonist of GPR120 (EC50s = 0.5, 0.63, and 0.79 µM for human, mouse, and rat receptors, respectively).{28990,28870} It is selective for GPR120 over a panel of 61 other targets, including other FFARs. Like the natural GPR120 ligand linoleic acid, GSK137647A dose-dependently stimulates insulin secretion by mouse insulinoma MIN6 cells under high glucose conditions.{28870} It also modestly stimulates the production of glucagon-like peptide-1 in taste bud cells and human intestinal NCI-H716 cells.{28990,28870}  

 

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Description

A selective agonist of GPR120 (EC50s = 0.5, 0.63, and 0.79 µM for human, mouse, and rat receptors, respectively); dose-dependently stimulates insulin secretion by mouse insulinoma MIN6 cells under high glucose conditions

Formal name: 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide

Synonyms: 

Molecular weight: 305.4

CAS: 349085-82-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Lipid Biochemistry|Fatty Acids

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