A SMO agonist that can promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 µM); used to characterize a novel SMO active site since it does not recognize the classic cyclopamine binding site utilized by other SMO agonists

GSA 10 – 25 mg

Brand:
Cayman
CAS:
300833-95-8
Storage:
-20
UN-No:
Non-Hazardous - /

Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.{21774} GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO.{26551} By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 µM).{26551} Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.{26551}  

 

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Description

A SMO agonist that can promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 µM); used to characterize a novel SMO active site since it does not recognize the classic cyclopamine binding site utilized by other SMO agonists

Formal name: 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester

Synonyms: 

Molecular weight: 450.5

CAS: 300833-95-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Stem Cell Research|Differentiation

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