An antiviral nucleoside analog; metabolized to an active triphosphate form that induces RNA chain termination and inhibits viral polymerases; active against MERS-CoV and SARS-CoV in infected primary HAE cells (EC50s = 0.86 and 0.18 µM

GS-441524 – 5 mg

Brand:
Cayman
CAS:
1191237-69-0
Storage:
-20
UN-No:
Non-Hazardous - /

GS-441524 is an antiviral nucleoside analog and a metabolite of remdesivir (Item No. 30354).{45842} Upon entry into cells, GS-441524 is metabolized to an active triphosphate form that induces RNA chain termination and inhibits viral polymerases. It is active against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) in infected primary human airway epithelial (HAE) cells (EC50s = 0.86 and 0.18 µM, respectively). GS-441524 reduces viral plaque formation in SARS-CoV-2-infected Vero E6 and Calu-3 2B4 cells (EC50s = 0.42 and 0.62 mM, respectively).{61140} It is cytoprotective against hepatitis C virus (HCV), yellow fever virus (YFV), dengue virus type 2 (DENV-2), influenza A, and parainfluenza 3 in cell-based assays (EC50s = 4.1, 11, 9.46, 27.9, and 1.71 µM, respectively).{53439}  

 

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Description

An antiviral nucleoside analog; metabolized to an active triphosphate form that induces RNA chain termination and inhibits viral polymerases; active against MERS-CoV and SARS-CoV in infected primary HAE cells (EC50s = 0.86 and 0.18 µM, respectively); reduces viral plaque formation in SARS-CoV-2-infected Vero E6 and Calu-3 2B4 cells (EC50s = 0.42 and 0.62 mM, respectively); cytoprotective against HCV, YFV, DENV-2, influenza A, and parainfluenza 3 in cell-based assays (EC50s = 4.1, 11, 9.46, 27.9, and 1.71 µM, respectively)

Formal name: 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile

Synonyms: 

Molecular weight: 291.3

CAS: 1191237-69-0

Purity: ≥98%

Formulation: A solid

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