A channel-forming ionophore; a peptide component of the antibiotic gramicidin; forms channels in model membranes that are permeable to monovalent cations

Gramicidin A – 1 mg

Brand:
Cayman
CAS:
11029-61-1
Storage:
-20
UN-No:
Non-Hazardous - /

Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis.{47164} Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. It induces degradation of hypoxia inducible factor 1 α (HIF-1α) in HEK293 cells and reduces growth in a human renal cell carcinoma mouse xenograft model when administered at a dose of 0.22 mg/kg three times per week.{47165} Gramicidin A has commonly been used to study channel structure and function.{47164}  

 

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Description

A channel-forming ionophore; a peptide component of the antibiotic gramicidin; forms channels in model membranes that are permeable to monovalent cations, protons, and water; induces degradation of HIF-1α in HEK293 cells and reduces growth in a human renal cell carcinoma mouse xenograft model at 0.22 mg/kg three times per week; reduces viral yield in WI-38 fibroblasts inoculated with isolates of HSV-1 and HSV-2 (IC50 = 0.3 µg/ml for all); commonly been used to study channel structure and function

Formal name: (R)-2-((2S,5R,8S,11R,14S,17R,20S,26S)-2-((1H-indol-3-yl)methyl)-17-isobutyl-5,8,11,26-tetraisopropyl-14,20-dimethyl-4,7,10,13,16,19,22,27,28-nonaoxo-3,6,9,12,15,18,21,24,25-nonaazaoctacosanamido)-N-((5S,8R,11S,14R,17S)-5,11-bis((1H-indol-3-yl)methyl)-1-hydroxy-18-(1H-indol-3-yl)-8,14-diisobutyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecan-17-yl)-4-methylpentanamide

Synonyms: 

Molecular weight: 1,882.30

CAS: 11029-61-1

Purity: ≥90%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Ionophores||Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer|Transcription Factors|HIF-1α||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease

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