A racemic mixture of natural polyphenols that inhibits spermatogenesis; has antimalarial properties

Gossypol – 500 mg

Brand:
Cayman
CAS:
303-45-7
Storage:
-20
UN-No:
Non-Hazardous - /

Gossypol is a racemic mixture of natural polyphenols isolated from parts of the cotton plant (genus Gossypium). It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans.{23003} Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations.{23001} It inhibits aldose reductase (Ki = 0.5 µM).{23002} Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations.{23000}  

 

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Description

A racemic mixture of natural polyphenols that inhibits spermatogenesis; has antimalarial properties, preventing the growth of P. falciparum; inhibits aldose reductase (Ki = 0.5 µM); inhibits growth in various cancer cell lines at low micromolar concentrations

Formal name: 1,1’,6,6’,7,7’-hexahydroxy-3,3’-dimethyl-5,5’-bis(1-methylethyl)-[2,2’-binaphthalene]-8,8’-dicarboxaldehyde

Synonyms:  BL 193|NSC 56817|NSC 624336|Pogosin

Molecular weight: 518.6

CAS: 303-45-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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