A synthetic GNRH agonist; binds to the GNRHR (Ki = 1.6 nM in CHO cells expressing the human receptor); binds to mouse pituitary αT3-1 cells and human placenta (Kds = 2 and 580 nM

Goserelin (acetate) – 1 mg

Brand:
Cayman
CAS:
145781-92-6
Storage:
-20
UN-No:
Non-Hazardous - /

Goserelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 1.6 nM, in CHO cells expressing the human receptor).{36464} It binds to mouse pituitary αT3-1 cells and human placenta (Kds = 2 and 580 nM, respectively) and increases intracellular calcium in αT3-1 cells.{36465} Goserelin induces testosterone production in vitro within 4 h in rat Leydig cells (ED50 = 83 nM) but decreases testosterone plasma level in vivo in rats over a period of 2 to 24 weeks.{36466,36467} It inhibits tumor growth in a DU145 human prostate carcinoma mouse xenograft model when administered at a dose of 100 μg per day.{36468} Formulations containing goserelin have been used in the treatment of hormone-dependent breast and prostate cancers, as well as endometriosis and uterine fibroids.  

 

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SKU: 24071 - 1 mg Category:

Description

A synthetic GNRH agonist; binds to the GNRHR (Ki = 1.6 nM in CHO cells expressing the human receptor); binds to mouse pituitary αT3-1 cells and human placenta (Kds = 2 and 580 nM, respectively) and increases intracellular calcium in αT3-1 cells; induces testosterone production in vitro within 4 h in rat Leydig cells (ED50 = 83 nM) but decreases testosterone plasma level in vivo in rats over a period of 2 to 24 weeks; inhibits tumor growth in a DU145 human prostate carcinoma mouse xenograft model (100 μg per day)

Formal name: 2-(aminocarbonyl)hydrazide-6-[O-(1,1-dimethylethyl)-D-serine]-1-9-luteinizing hormone-releasing factor (swine), acetate

Synonyms: 

Molecular weight: 1,269.40

CAS: 145781-92-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Reproductive Biology

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