A lignan; inhibits HIV-1 IIIB replication in H9 T cells (EC50 = 1.5 µg/ml); decreases LPS-induced NO production and p38

Gomisin J – 5 mg

Brand:
Cayman
CAS:
66280-25-9
Storage:
-20
UN-No:
Non-Hazardous - /

Gomisin J is a lignan that has been found in Schisandra chinensis and has diverse biological activities.{52505,52506} It inhibits HIV-1 IIIB replication in H9 T cells (EC50 = 1.5 µg/ml).{52505} Gomisin J (20 µM) decreases LPS-induced increases in nitric oxide (NO) production and p38, ERK, and JNK phosphorylation in RAW 264.7 cells.{52506} It induces relaxation of isolated, precontracted endothelium-intact rat aortic rings when used at concentrations of 3, 10, and 30 µg/ml.{52508} Gomisin J is cytotoxic to 13 cancer cell lines, including breast, colon, and cervical cancer cells, when used at a concentration of 30 µg/ml.{52507}  

 

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SKU: 30213 - 5 mg Category:

Description

A lignan; inhibits HIV-1 IIIB replication in H9 T cells (EC50 = 1.5 µg/ml); decreases LPS-induced NO production and p38, ERK, and JNK phosphorylation in RAW 264.7 cells; induces relaxation of isolated, precontracted endothelium-intact rat aortic rings at 3, 10, and 30 µg/ml; cytotoxic to 13 cancer cell lines at 30 µg/ml;

Formal name: (6R,7S,12aS)-5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-dibenzo[a,c]cyclooctene-3,10-diol

Synonyms: 

Molecular weight: 388.5

CAS: 66280-25-9

Purity: ≥98%

Formulation: A crystalline solid

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